Search results for "messenger RNA"
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mRNA: The Messenger - mRNA Synthesis
Explore the mRNA universe with Cytiva.
Join us for part 3 of mRNA: the messenger, where we discuss key considerations for the synthesis of RNA molecules, including optimizing the…
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Enhancing Resins Addresses Purification Concerns
What COVID-19 brings to the table
The COVID-19 vaccines comprise several possible and different modalities, such as messenger RNA (mRNA), attenuated viruses, viral vectors, proteins, and virus l…
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Can Vaccine Development Be Safely Accelerated?
Prophylactic messenger RNA vaccines
Two companies, both also supported by grants from CEPI, have developed platform technologies based on messenger RNA (mRNA). Cambridge, MA-based Moderna—which ha…
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
…ss in mammalian cells that removes introns and joins exons in a primary transcript to create mature messenger RNA (mRNA) for translation. For biopharmaceutical development, the recombinant genes codi…
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Genetic Vaccine Platforms Demonstrate Their Potential
Genetic vaccines include messenger RNA (mRNA)/DNA. Alternatively, vaccines can be classified into live and non-live vaccines, which is important when considering safety profiles.
Traditional v…
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A Closer Look at Affinity Ligands
…tography stationary phases to provide a highly specific ligand for the polyadenylated tail of mRNA [messenger RNA] molecules. The emergence of this class of therapeutic molecules (mRNAs) drove the de…
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Discussing the Origins of the mRNA Therapeutics Field
Andy Geall, co-founder and chief development officer at Replicate Bioscience, discusses the historical context and buildup of the mRNA therapeutics field.
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Need solutions for large-scale production of mRNA-based molecules?
Therapies based on messenger RNA, such as mRNA vaccines, have revolutionary potential. mRNA therapeutics offer precise and individualized therapy and avoid manufacturing issues associated wit…
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Top Process Development Trends for 2021 and a Look into 2022
However, the focus in 2021 shifted beyond the pandemic to optimization and scaling up adeno-associated virus (AAV) production, process workflows and considerations for messenger RNA (mRNA) therapeutic…
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Maximum Output Starts with Optimized Upstream Processing
… first authorized candidates are based on adenoviral technology (AstraZeneca/Oxford and Janssen) or messenger RNA (mRNA) (Pfizer-BioNTech, Moderna), with candidates still in development being DNA-bas…